Did you know?
Inherited gene mutation is responsible to contribute to about 10% of breast cancers.
Who should consider for genetic testing for cancer risk?
The features of a person’s personal or family medical history that, particularly in combination, may suggest a hereditary cancer syndrome include:
- Cancer was diagnosed at an unusually young age
- Several different types of cancer occurred in the same person
- Cancer in both organs in a set of paired organs, such as both kidneys or both breasts
- Several first-degree relatives (the parents, siblings, or children of an individual) have the same type of cancer (for example, a mother, daughter, and sisters with breast cancer); family members with breast or ovarian cancer; family members with colon cancer and endometrial cancer
- Unusual cases of a specific cancer type (for example, breast cancer in a man)
- The presence of birth defects that are known to be associated with inherited cancer syndromes, such as certain noncancerous (benign) skin growths and skeletal abnormalities associated with neurofibromatosis type 1.
- Being a member of a racial or ethnic group that is known to have an increased risk of having a certain inherited cancer susceptibility syndrome and having one or more of the above features as well
- Several family members with cancer
BRCA mutations are responsible for the majority of hereditary breast and ovarian cancers.
- BRCA1 and BRCA2 are human genes that produce tumor suppressor proteins.
- These proteins help in repairing damaged DNA and, therefore, plays a crucial role in ensuring the stability of the cell’s genetic material.
- When either of these genes is mutated, or altered, such that its protein product is not made or does not function correctly, DNA damage may not be repaired properly.
- As a result, cells are more likely to develop additional genetic alterations that can lead to cancer or related tumors growth.
- A harmful BRCA1 or BRCA2 mutation can be inherited from a person’s mother or father.
- Genetic Testing can be done to identify if Inherited BRCA gene mutation or any other oncogene panel responsible for Breast cancer.
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Frequently Asked Questions (FAQ)
What is the cost of Genetic Testing?
– Genetic Testing costs Rs.10,500 /- Only*
What is included in the Cost?
– Genetic Testing
– Home Sample Collection
– Free Counselling
How is genetic testing done?
– Genetic Testing is done on a small sample of bodily fluid or tissue—usually blood.
What do the results of genetic testing mean?
– Positive result – Confirm that the cancer was likely due to an inherited genetic variant
– Negative result – Does not have inherited genetic variant present in their family
– Variant of uncertain significance – A change that has not been previously associated with cancer
– Benign variant – Common in the general population among people without cancer
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MBC is an organization formed & lead by Dr. Tushar Jadhav & Dr. Amit Patil, trained from apex cancer institute of India i.e. Tata Memorial Hospital, Mumbai. It is based in Mumbai & Maharashtra with operational tie ups with multiple charitable institutes & corporates across Mumbai & Maharashtra.